Gan, Liang-Shang: search on Z-Library

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1

Plasma protein binding: From discovery to development

Bohnert, Tonika, Gan, Liang-Shang

Journal:

Journal of Pharmaceutical Sciences

Year:

2013

Language:

english

File:

PDF, 4.22 MB

english, 2013

2

Strategy of Utilizing In Vitro and In Vivo ADME Tools for Lead Optimization and Drug Candidate Selection

Balani, Suresh, Miwa, Gerald, Gan, Liang-Shang, Wu, Jing-Tao, Lee, Frank

Journal:

Current Topics in Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 89 KB

english, 2005

3

Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

Xia, Cindy Q., Xiao, Guangqing, Liu, Ning, Pimprale, Satish, Fox, Lisa, Patten, Chris J., Crespi, Charles L., Miwa, Gerald, Gan, Liang-Shang

Journal:

Molecular Pharmaceutics

Year:

2006

Language:

english

File:

PDF, 245 KB

english, 2006

4

Use of CACO-2 Cells as an in vitro Intestinal Absorption and Metabolism Model

Gan, Liang-Shang, Eads, Cindy, Niederer, Tara, Bridgers, Avis, Yanni, Souzan, Hsyu, Poe-Hirr, Pritchard, Fred J., Thakker, Dhiren

Journal:

Drug Development and Industrial Pharmacy

Year:

1994

Language:

english

File:

PDF, 835 KB

english, 1994

5

Pharmacokinetics of Oral Tonapofylline and Its Acyl-Glucuronide Metabolite in Patients With Mild and Moderate Hepatic Impairment

Li, Zhaoyang, Gan, Liang-Shang, Marbury, Thomas, Lasseter, Kenneth C., Natarajan, Amy, Stecher, Scott, Wei, Dong, Yang, Liyu, Freedman, Daniel, Deykin, Aaron

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 340 KB

english, 2012

6

Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

Xiao, Guangqing, Gan, Liang-Shang

Journal:

International Journal of Cell Biology

Year:

2013

Language:

english

File:

PDF, 1.69 MB

english, 2013

7

Quantitation of carcinogen bound protein adducts by fluorescence measurements

Liang-Shang Gan, Michael S. Otteson, Mark M. Doxtader, Paul L. Skipper, Ramachandra R. Dasari, Steven R. Tannenbaum

Journal:

Spectrochimica Acta Part A: Molecular Spectroscopy

Year:

1989

Language:

english

File:

PDF, 386 KB

english, 1989

8

Disposition of 1-[3-(Aminomethyl)phenyl]- N -[3-fluoro-2‘- (methylsulfonyl)-[1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)- 1 H -pyrazole-5-carboxamide (DPC 423) by Novel Metabolic Pathways. Characterization of Unusual Metabolites by Liquid Chromatography/Mass Spectrometry and NMR

Mutlib, Abdul. E., Shockcor, John, Chen, Shiang-Yuan, Espina, Robert J., Pinto, Donald J., Orwat, Michael J., Prakash, Shimoga R., Gan, Liang-Shang

Journal:

Chemical Research in Toxicology

Year:

2002

Language:

english

File:

PDF, 193 KB

english, 2002

9

Fampridine is a Substrate and Inhibitor of Human OCT2, but not of Human MATE1, or MATE2K

Xiao, Guangqing, Rowbottom, Christopher, Boiselle, Carri, Gan, Liang-Shang

Journal:

Pharmaceutical Research

Year:

2018

Language:

english

File:

PDF, 1.35 MB

english, 2018

10

Characterization of Novel Glutathione Adducts of a Non-Nucleoside Reverse Transcriptase Inhibitor, ( S )-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydro-2(1 H )-quinazolinone (DPC 961), in Rats. Possible Formation of an Oxirene Metabolic Intermediate from a Disubstituted Alkyne

Mutlib, Abdul, Chen, Hao, Shockcor, John, Espina, Robert, Chen, Sy, Cao, Kevin, Du, Alicia, Nemeth, Greg, Prakash, Shimoga, Gan, Liang-Shang

Journal:

Chemical Research in Toxicology

Year:

2000

Language:

english

File:

PDF, 151 KB

english, 2000

11

P450-Mediated Metabolism of 1-[3-(Aminomethyl)phenyl]- N -[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1 H -pyrazole- 5-carboxamide (DPC 423) and Its Analogues to Aldoximes. Characterization of Glutathione Conjugates of Postulated Intermediates Derived from Aldoximes

Mutlib, Abdul E., Chen, Shiang-Yuan, Espina, Robert J., Shockcor, John, Prakash, Shimoga R., Gan, Liang-Shang

Journal:

Chemical Research in Toxicology

Year:

2002

Language:

english

File:

PDF, 182 KB

english, 2002

12

Effects of acetylenic and olefinic pyrenes upon cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes

Liang-Shang L. Gan, Jui-Yun L. Lu, Douglas M. Hershkowitz, William L. Alworth

Journal:

Biochemical and Biophysical Research Communications

Year:

1985

Language:

english

File:

PDF, 382 KB

english, 1985

13

Oxidative Deboronation of the Peptide Boronic Acid Proteasome Inhibitor Bortezomib: Contributions from Reactive Oxygen Species in This Novel Cytochrome P450 Reaction

Labutti, Jason, Parsons, Ian, Huang, Ron, Miwa, Gerald, Gan, Liang-Shang, Daniels, J. Scott

Journal:

Chemical Research in Toxicology

Year:

2006

Language:

english

File:

PDF, 390 KB

english, 2006

14

Quantitation of methylated hemoglobin via hydrolysis of methyl esters to yield methanol

Liang-Shang Gan, John S. Wishnok, James G. Fox, Steven R. Tannenbaum

Journal:

Analytical Biochemistry

Year:

1989

Language:

english

File:

PDF, 637 KB

english, 1989

15

Mechanism of Intestinal Absorption of Ranitidine and Ondansetron: Transport Across Caco-2 Cell Monolayers

Liang-Shang Gan, Poe-Hirr Hsyu, J. Frederick Pritchard, Dhiren Thakker

Journal:

Pharmaceutical Research

Year:

1993

File:

PDF, 824 KB

1993

16

Delineating Novel Metabolic Pathways of DPC 963, a Non-Nucleoside Reverse Transcriptase Inhibitor, in Rats. Characterization of Glutathione Conjugates of Postulated Oxirene and Benzoquinone Imine Intermediates by LC/MS and LC/NMR

Chen, Hao, Shockcor, John, Chen, Weiqi, Espina, Robert, Gan, Liang-Shang, Mutlib, A. E.

Journal:

Chemical Research in Toxicology

Year:

2002

Language:

english

File:

PDF, 168 KB

english, 2002

17

P-Glycoprotein and Breast Cancer Resistance Protein Affect Disposition of Tandutinib, A Tyrosine Kinase Inhibitor

J. Yang, Johnny, N. Milton, Mark, Yu, Shaoxia, Liao, Mingxiang, Liu, Ning, Wu, Jing-Tao, Gan, Liang-Shang, K. Balani, Suresh, W. Lee, Frank, Prakash, Shimoga, Q. Xia, Cindy

Journal:

Drug Metabolism Letters

Year:

2010

Language:

english

File:

PDF, 456 KB

english, 2010

18

Modulation of the Tight Junctions of the Caco-2 Cell Monolayers by H2-antagonists

Liang-Shang L. Gan, Souzan Yanni, Dhiren R. Thakker

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 441 KB

1998

19

Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

Liang-Shang L. Gan, Dhiren R. Thakker

Journal:

Advanced Drug Delivery Reviews

Year:

1997

Language:

english

File:

PDF, 2.03 MB

english, 1997

20

Breast cancer resistance protein in pharmacokinetics and drug–drug interactions

Xia, Cindy Q, Yang, Johnny J, Gan, Liang-Shang

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2005

Language:

english

File:

PDF, 304 KB

english, 2005

21

Mechanistic study of potentiation of chemotherapy by a haloenol lactone derivative in vitro

Wei Wang, Cindy Q. Xia, Ning Liu, Liang-Shang Gan, Jiang Zheng

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 253 KB

english, 2008

22

Gas chromatographic—mass spectrometric analysis of diols and tetrols from reactions of polycyclic aromatic hydrocarbon epoxides with hemoglobin

Billy W. Day, Stephen Naylor, Liang-Shang Gan, Yousif Sahali, Thanh T. Nguyen, Paul L. Skipper, John S. Wishnok, Steven R. Tannenbaum

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1991

Language:

english

File:

PDF, 338 KB

english, 1991

23

Serum albumin adducts in the molecular epidemiology of aflatoxin carcinogenesis: correlation with aflatoxin B 1 intake and urinary excretion of aflatoxin M 1

Gan, Liang-Shang, Skipper, Paul L., Peng, Xiaocong, Groopman, John D., Chen, Jun-shi, Wogan, Gerald N., Tannenbaum, Steven R.

Journal:

Year:

1988

Language:

english

File:

PDF, 336 KB

english, 1988

24

Identification and characterization of oxymetazoline glucuronidation in human liver microsomes: Evidence for the involvement of UGT1A9

Mukesh K. Mahajan, Vinita Uttamsingh, Liang-Shang Gan, Barbara Leduc, David A. Williams

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 386 KB

english, 2011

25

Bioactivation of Benzylamine to Reactive Intermediates in Rodents: Formation of Glutathione, Glutamate, and Peptide Conjugates

Mutlib, Abdul E., Dickenson, Patricia, Chen, Shiang-Yuan, Espina, Robert J., Daniels, J. Scott, Gan, Liang-Shang

Journal:

Chemical Research in Toxicology

Year:

2002

Language:

english

File:

PDF, 344 KB

english, 2002

26

Evaluation of Drug-Transporter Interactions Using In Vitro and In Vivo Models

Xia, Cindy, Milton, Mark, Gan, Liang-Shang

Journal:

Current Drug Metabolism

Year:

2007

Language:

english

File:

PDF, 972 KB

english, 2007

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